Why some women can't donate plasma for Covid-19 patient

Why some women can't donate plasma for Covid-19 patient

Convalescent plasma — the liquid part of the blood containing antibodies against SARS-Cov-2 developed in patients who have recovered from Covid-19 — has become a sought-after therapy in several cases to cure people suffering from the viral infection. There are however, certain conditions about who can and who cannot donate plasma — and one category is women who have ever been pregnant.Why is that? According to medical experts, women, during their pregnancy develop antibodies — called human leucocyte antigens (HLA) — against the father's genetic material. In fact, greater the number of successful pregnancies a woman has, greater the HLA count.Once developed, they are present in the blood forever. Though HLA antibodies are not harmful to the person who made them, if transfused to another person they can cause a rare but serious complication in the transfusion recipients known as Transfusion-Related Acute Lung Injury (TRALI).Since Covid-19 patients requiring plasma transfusion usually have their lungs weakened by the virus, transfusing the plasma of a woman who's been pregnant in her life could prove fatal.It isn't just women though — several men too won't make the list of plasma donors since the requirements are extremely strict. For one, plasma can only be donated after a minimum of 14 days from recovery. Donors need to be at least 18 years old and not more than 60 years of age, weigh at least 50 kg, have a haemoglobin count of at least 8, do not suffer from any chronic kidney, heart, lung or liver disease and don ...
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